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Фото: Владимир Астапкович / РИА Новости

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Agar was first introduced into the laboratory in 1881. Since then, microbiologists have depended on agar to create strong jellies. When microorganisms are streaked or plated onto this jellied surface and incubated, individual cells multiply into distinct colonies that scientists can easily observe, select, and propagate for further experiments. Many of the most important findings in biological research of the last 150 years or so — including the discovery of the CRISPR/Cas9 gene-editing tool — have been enabled by agar.4 Agarose, a derivative of agar, is also essential in molecular biology techniques like gel electrophoresis, where its porous gel matrix separates DNA fragments by size, enabling researchers to analyze and isolate specific genetic sequences.

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有趣的是,Infigratinib最初于2021年获批用于胆管癌,后因适应症开发策略调整而主动撤回。如今,其有望在ACH赛道迎来“第二春”。基于其疗效和口服便利性,BridgeBio在今年的JPM大会上预测,该药Infigratinib将占据ACH治疗市场50%以上的份额。

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